IL-10 predicts the prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure combined with spontaneous bacterial peritonitis

Background Spontaneous bacterial peritonitis (SBP) is common in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). The prognostic value of interleukin-related serum markers for ACLF coming to the fore. However, there an unmet need predict survival such patients. We aimed analyze independent predictors 28- and 90-day mortality HBV-ACLF SBP. Methods This was a retrospective study that included 368 HBV-ACLF. In SBP group, logistic regression analysis used understand at 28-day 90-day. accuracy prediction analyzed using area under receiver operating characteristic curve (AUROC). Finally, decision (DCA) determine clinical utility value. Results Interleukin 10 (IL-10) levels were statistically significantly different between group without. Aspartate aminotransferase (AST), sodium, IL-10 vasoactive drug treatment risk factors mortality. International normalized ratio (INR), AST combined Chinese Severe Hepatitis Study Group-ACLF II score (COSH-ACLF IIs) had excellent performance predicting (AUCs: 0.848 0.823, respectively). DCA suggests promising utility. Conclusion predictor predictive improved when COSH-ACLF IIs.